A Randomized Comparison of Cefoxitin with or without Amikacin and Clindamycin plus Amikacin in Surgical Sepsis
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چکیده
منابع مشابه
Glomerular Filtration Rate Changes in Neonates with Sepsis Treated with Amikacin and Cefotaxime
Background and purpose: Aminoglycosides (AG) such as Amikacin that are widely used to prevent and treat infections in neonates have nephrotoxic effects. The aim of this study was to evaluate the role of urinary index to Glomerular filtration rate (GFR) in diagnosis of tubular renal injury following administration of Amikacin in neonates admitted to neonatal intensive care unit (NICU). Materia...
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15 صفحه اولis ceftizoxime an appropriate surrogate for amikacin in neonatal sepsis treatment? a randomized clinical trial
neonatal sepsis, a life-threatening condition, presents with non-specific clinical manifestations and needs immediate empirical antimicrobial therapy. choosing an appropriate antibiotic regimen covering the most probable pathogens is an important issue. in this study we compared the effectiveness of ceftizoxime and amikacin in the treatment of neonatal sepsis both in combination with ampicillin...
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BACKGROUND The therapeutic effect of aminoglycosides is highest and optimal when the peak plasma concentration (C max)/minimal inhibitory concentration (MIC) ratio is between 8 and 10. The French guidelines recommend to use high doses of aminoglycosides for empiric antibiotic therapy in patients suffering from severe sepsis or septic shock. In clinical practice, the recommended target is an ami...
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BACKGROUND Standard therapy for suspected infections in patients with profound neutropenia is the combination of a beta-lactam antibiotic plus an aminoglycoside. Cefepime's broad-spectrum activity makes it an option for initial empirical therapy in neutropenic patients. The aim of this study is to evaluate the efficacy and safety of cefepime plus amikacin compared with piperacillin-tazobactam p...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1981
ISSN: 0003-4932
DOI: 10.1097/00000658-198103000-00011